OZO-Cl

OZO-Cl is an OZO derivative. OZO-Cl has anti-cancer activity. OZO-Cl significantly decreases the intracellular glutathion S-transferase Pi (GST) activity. OZO-Cl exhibits cytotoxicity to cancer cell lines, with IC50s of 150 and 120 μmol/L in Panc-1 and K562 cells respectively[1].

Product Specifications

CAS Number

[2201798-21-0]

UNSPSC

12352101

Target

Glutathione S-transferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer

Smiles

[O-]C1=C(C2=CC=C(Cl)C=C2)[S+]=NO1

Molecular Formula

C8H4ClNO2S

Molecular Weight

213.64

References & Citations

[1]Cui, H., et al., (2008) . 4-Aryl-1,3,2-oxathiazolylium-5-olate: a novel GST inhibitor to release JNK and activate c-Jun for cancer therapy. Cancer chemotherapy and pharmacology, 62 (3), 509–515.