Onychocin B
Onychocin B is a cyclic tetrapeptide isolated from Onychocola sclerotica. Onychocin B is a calcium channel blocker with an IC50 of 7.1 μM for Cav1.2[1].
Product Specifications
UNSPSC
12352005
Target
Calcium Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
O=C([C@H]([C@@H](C)CC)NC([C@H](CC1=CC=CC=C1)N(C)C([C@H](C(C)C)N2)=O)=O)N(C)[C@H](CC3=CC=CC=C3)C2=O
Molecular Formula
C31H42N4O4
Molecular Weight
534.69
References & Citations
[1]Pérez-Victoria I, Martín J, et al. Isolation and structural elucidation of cyclic tetrapeptides from Onychocola sclerotica. J Nat Prod. 2012 Jun 22;75 (6) :1210-4.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
L-type calcium channel
Curated Selection
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