PROTAC sEH-degrader-3
PROTAC sEH-degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH-degrader-3 degrades sEH through a CRBN-dependent lysosomal pathway rather than the proteasome, with an IC50 of 0.8 nM against hsEH. PROTAC sEH-degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress. (Pink: sEH inhibitor (HY-114266) ; Black: Linker (HY-W008352) ; Blue: E3 Ligase Ligand (HY-14658) ) [1].
Product Specifications
CAS Number
[3093413-94-3]
UNSPSC
12352005
Target
Epoxide Hydrolase; PROTACs
Related Pathways
Metabolic Enzyme/Protease; PROTAC
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology
Smiles
O=C(COC1=C(C2=O)C(C(N2C3CCC(NC3=O)=O)=O)=CC=C1)NCCOCCOCCOCCOCCNC(C4=CC=C(O[C@@H]5CC[C@H](CC5)NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)C=C4)=O
Molecular Formula
C46H53F3N6O14
Molecular Weight
970.94
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
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