6-Thioguanosine-5'-O-diphosphate (sodium)
6-Thioguanosine-5'-O-diphosphate sodium (6-Thio-GDP sodium) (TGDP sodium) is an active metabolite of 6-Mercaptopurine. 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug[1][2].
Product Specifications
Product Name Alternative
TGDP (sodium) ; 6-Thio-GDP (sodium)
UNSPSC
12352005
Target
Endogenous Metabolite
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Inflammation/Immunology
Smiles
O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=S)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O
Molecular Formula
C10H12N5Na3O10P2S
Molecular Weight
525.21
References & Citations
[1]Hawwa AF, et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br J Clin Pharmacol. 2008 Oct;66 (4) :517-28. |[2]Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305 (9) :E1081-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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