6-Thioguanosine-5'-O-diphosphate (sodium)

6-Thioguanosine-5'-O-diphosphate sodium (6-Thio-GDP sodium) (TGDP sodium) is an active metabolite of 6-Mercaptopurine (HY-13677) . 6-Mercaptopurine is a purine analogue which acts as an antagonist of the endogenous purines and has been widely used as antileukemic agent and immunosuppressive drug[1][2].

Product Specifications

Product Name Alternative

TGDP (sodium) ; 6-Thio-GDP (sodium)

UNSPSC

12352005

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Inflammation/Immunology

Smiles

O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=S)O[C@@H]1COP(OP(O[Na])(O[Na])=O)(O[Na])=O

Molecular Formula

C10H12N5Na3O10P2S

Molecular Weight

525.21

References & Citations

[1]Hawwa AF, et al. Pharmacogenomic studies of the anticancer and immunosuppressive thiopurines mercaptopurine and azathioprine. Br J Clin Pharmacol. 2008 Oct;66 (4) :517-28. |[2]Liu Q, et al. 6-Mercaptopurine augments glucose transport activity in skeletal muscle cells in part via a mechanism dependent upon orphan nuclear receptor NR4A3. Am J Physiol Endocrinol Metab. 2013 Nov 1;305 (9) :E1081-92.