ZLN005 (hydrochloride)
ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity[1].
Product Specifications
CAS Number
2319647-97-5
UNSPSC
12352005
Target
PGC-1α
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
CC(C)(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)C.Cl
Molecular Formula
C17H19ClN2
Molecular Weight
286.80
References & Citations
[1]Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62 (4) :1297-307.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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