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ZLN005 (hydrochloride)

ZLN005 (hydrochloride) is a peroxisome proliferator-activated receptor-g coactivator-1a (PGC-1α) activator. ZLN005 (hydrochloride) can stimulate the expression of PGC-1α and downstream genes in skeletal muscle cells, improve glucose utilization and fatty acid oxidation. ZLN005 (hydrochloride) can increase the transcription of PGC-1α and downstream genes in skeletal muscle of diabetic db/db mice, increase fat oxidation and improve glucose tolerance, pyruvate tolerance and insulin sensitivity[1].

Product Specifications

CAS Number

[2319647-97-5]

UNSPSC

12352005

Target

PGC-1α

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

CC(C)(C1=CC=C(C2=NC3=CC=CC=C3N2)C=C1)C.Cl

Molecular Formula

C17H19ClN2

Molecular Weight

286.80

References & Citations

[1]Zhang LN, et al. Novel small-molecule PGC-1α transcriptional regulator with beneficial effects on diabetic db/db mice. Diabetes. 2013 Apr;62 (4) :1297-307.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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