D-myo-Inositol-1,3,4-triphosphate (sodium)

D-myo-Inositol-1,3,4-triphosphate (sodium) is one of the inositol oligophosphate isomers implicated in signal transduction. D-myo-Inositol-1,3,4-triphosphate (sodium) acts through the inhibition of Ins (3,4,5,6) -P4 kinase activity to increase cellular level of Ins (3,4,5,6) -P4, thereby inhibiting calcium-activated chloride channels. D-myo-Inositol-1,3,4-triphosphate (sodium) can be regulated by the levels of cytosolic free calcium[1][2].

Product Specifications

Product Name Alternative

Ins (1,3,4) -P3 (sodium) ; 1,3,4-IP3 (sodium)

UNSPSC

12352211

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

O[C@H]1[C@H]([C@@H]([C@H]([C@@H]([C@H]1OP(O)(O[Na])=O)OP(O)(O[Na])=O)O)O)OP(O)(O[Na])=O

Molecular Formula

C6H12Na3O15P3

Molecular Weight

486.04

References & Citations

[1]Lew, P. D., et al., (1986) . The role of cytosolic free calcium in the generation of inositol 1,4,5-trisphosphate and inositol 1,3,4-trisphosphate in HL-60 cells. Differential effects of chemotactic peptide receptor stimulation at distinct Ca2+ levels. The Journal of biological chemistry, 261 (28), 13121–13127.