D-myo-Inositol-4,5-diphosphate (sodium)

D-myo-Inositol-4,5-diphosphate (sodium) is one of the members in inositol phosphate family of second messengers that play an important role in transmitting cellular signals. D-myo-Inositol-4,5-diphosphate (sodium) can open calcium channels and increase intracellular calcium upon binding to its receptor on the endoplasmic reticulum[1][2][3].

Product Specifications

CAS Number

[208584-57-0]

Product Name Alternative

Ins (4,5) -P2 (sodium) ; 4,5-IP2 (sodium)

UNSPSC

12352211

Target

Endogenous Metabolite

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Smiles

O[C@@H]1[C@H]([C@@H]([C@H]([C@H]([C@H]1O)O)O)OP(O)(O[Na])=O)OP(O)(O[Na])=O

Molecular Formula

C6H12Na2O12P2

Molecular Weight

384.08

References & Citations

[1]Streb, H., et al., (1983) . Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature, 306 (5938), 67–69. |[2]Mikoshiba, K., et al., (1993) . Structure and function of inositol 1,4,5-trisphosphate receptor. Annals of the New York Academy of Sciences, 707, 178–197. |[3]Exton J. H. (1996) . Regulation of phosphoinositide phospholipases by hormones, neurotransmitters, and other agonists linked to G proteins. Annual review of pharmacology and toxicology, 36, 481–509. |[4]Yang, X., et al., (1999) . Inositol 1,3,4-trisphosphate acts in vivo as a specific regulator of cellular signaling by inositol 3,4,5,6-tetrakisphosphate. The Journal of biological chemistry, 274 (27), 18973–18980.