DeFer-2
DeFer-2 is a ferritin PROTAC degrader (Kd = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3-GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS. DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. (Pink: Oleic acid: HY-N1446, Blue: (S, R, S) -AHPC: HY-125845, Black: γ-Aminobutyric acid: HY-N0067, Blue + Black: (S, R, S) -AHPC-C3-NH2: HY-130711).
Product Specifications
CAS Number
3058911-16-0
UNSPSC
12352005
Target
Caspase; PROTACs; Pyroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=C(SC=N1)C2=CC=C(C=C2)CNC([C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCCNC(CCCCCCC/C=C\CCCCCCCC)=O)=O)=O)=O
Molecular Formula
C44H69N5O5S
Molecular Weight
780.11
References & Citations
[1]Chen Y, et al. Small-Molecule Ferritin Degrader as a Pyroptosis Inducer. J Am Chem Soc. 2023 May 3;145 (17) :9815-9824.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; von Hippel-Lindau (VHL)
Frequently Asked Questions
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