RIPK1 ligand-Linker Conjugate-1
RIPK1 ligand-Linker Conjugate-1 is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for RIPK1 (HY-175371) and a PROTAC linker (HY-175373), which recruits E3 ligases. RIPK1 ligand-Linker Conjugate-1 can be used for synthesis of PROTAC RIPK1 Degrader-1 (HY-175370) [1].
Product Specifications
UNSPSC
12352005
Target
RIP kinase; Target Protein Ligand-Linker Conjugates
Related Pathways
Apoptosis; PROTAC
Field of Research
Cancer
Smiles
O=C(N1CCC(CC1)CN2CCC(CN3CCN(CC(N)=O)CC3)CC2)CN4C=C(C=N4)C5=CN=C(N)C6=C5SC=C6C7=CC=C8N(C(CC9=CC=CC=C9)=O)CCC8=C7
Molecular Formula
C46H56N10O3S
Molecular Weight
829.07
References & Citations
[1]Zhang Z, et al. Development of Potent and Selective RIPK1 Degraders Targeting Its Nonenzymatic Function for Cancer Treatment. J Med Chem. 2025 Jul 24;68 (14) :15120-15136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1
Curated Selection
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