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H3R antagonist 7

H3R antagonist 7 (compounds 4) is a histamine subtype 3 receptor (H3R) antagonist with a Ki of 3.15 nM. H3R antagonist 7 is a potential PET radioligand for the study of central nervous system (CNS) diseases[1].

Product Specifications

UNSPSC

12352005

Target

Histamine Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(N1CCN(C2CCCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3

Molecular Formula

C20H27FN2O

Molecular Weight

330.44

References & Citations

[1]Song Z, et al. Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype-3 Receptor. J Med Chem. 2025 Jul 15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

H3 Receptor

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