H3R antagonist 7
H3R antagonist 7 (compounds 4) is a histamine subtype 3 receptor (H3R) antagonist with a Ki of 3.15 nM. H3R antagonist 7 is a potential PET radioligand for the study of central nervous system (CNS) diseases[1].
Product Specifications
UNSPSC
12352005
Target
Histamine Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(N1CCN(C2CCCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3
Molecular Formula
C20H27FN2O
Molecular Weight
330.44
References & Citations
[1]Song Z, et al. Development and Preclinical Characterization of [18F]H3-2406 and [18F]H3-2407 for Positron Emission Tomography Imaging of the Histamine Subtype-3 Receptor. J Med Chem. 2025 Jul 15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor
Curated Selection
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