H3R antagonist 6
H3R antagonist 6 (Compounds 3) (H3-2406) is a Histamine receptor 3 (H3R) antagonist with an IC50 of 5.6 nM. H3R antagonist 6 labeled with 18F has high radiochemical yield, molar activity and moderate brain uptake, but with an off-target binding to the Sigma-1 receptor. H3R antagonist 6 can be used as a PET radioligand for positron emission tomography imaging for central nervous system (CNS) disorders research[1].
Product Specifications
CAS Number
[2183338-59-0]
UNSPSC
12352005
Target
Histamine Receptor; Sigma Receptor
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N1CCN(C2CCCC2)CC1)[C@@H]3[C@@H](C4=CC=C(F)C=C4)C3
Molecular Formula
C19H25FN2O
Molecular Weight
316.41
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
H3 Receptor; Sigma 1 Receptor
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