DOR agonist 3
DOR agonist 3 (Compound 10) is a δ-opioid receptor (DOR) -selective positive allosteric modulator. DOR agonist 3 enhances G protein signaling while reducing β-arrestin2 recruitment. DOR agonist 3 is promising for research of chronic pain and depression[1].
Product Specifications
CAS Number
939956-07-7
UNSPSC
12352005
Target
Arrestin; Opioid Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
CC1=CC=CC=C1COC2=CC=C(C=C2)C3C4=C(NC5=NN=NN53)CC(C)(CC4=O)C
Molecular Formula
C24H25N5O2
Molecular Weight
415.49
References & Citations
[1]Deo O, et al. A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor. ACS Chem Neurosci. 2025 Aug 6;16 (15) :2958-2977.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Arrestin-3/β-Arrestin 2
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