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DOR agonist 3

DOR agonist 3 (Compound 10) is a δ-opioid receptor (DOR) -selective positive allosteric modulator. DOR agonist 3 enhances G protein signaling while reducing β-arrestin2 recruitment. DOR agonist 3 is promising for research of chronic pain and depression[1].

Product Specifications

CAS Number

939956-07-7

UNSPSC

12352005

Target

Arrestin; Opioid Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

CC1=CC=CC=C1COC2=CC=C(C=C2)C3C4=C(NC5=NN=NN53)CC(C)(CC4=O)C

Molecular Formula

C24H25N5O2

Molecular Weight

415.49

References & Citations

[1]Deo O, et al. A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor. ACS Chem Neurosci. 2025 Aug 6;16 (15) :2958-2977.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Arrestin-3/β-Arrestin 2

Frequently Asked Questions

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