GCS-12–6

GCS-12–6 is a potent Th2-selective NKT cell agonist targeting CD1d protein. GCS-12–6 is promising for research of autoimmune diseases (e.g., inflammatory bowel disease, multiple sclerosis) [1].

Product Specifications

UNSPSC

12352211

Target

CD1

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O

Molecular Formula

C42H84N2O11S

Molecular Weight

825.19

References & Citations

[1]Wen Y, et al. Significantly Boosted Th2-Selective Activity of NKT Cell Agonist Enabled by Sulfonamide Hydrogen-Bond Design. J Med Chem. 2025 Aug 14;68 (15) :15785-15797.