GCS-12–6
GCS-12–6 is a potent Th2-selective NKT cell agonist targeting CD1d protein. GCS-12–6 is promising for research of autoimmune diseases (e.g., inflammatory bowel disease, multiple sclerosis) [1].
Product Specifications
UNSPSC
12352211
Target
CD1
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
O[C@@H]([C@H](CO[C@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O)NC(CCCCCCCCCCCNS(=O)(CCCCCC)=O)=O)[C@@H](CCCCCCCCCCCCCC)O
Molecular Formula
C42H84N2O11S
Molecular Weight
825.19
References & Citations
[1]Wen Y, et al. Significantly Boosted Th2-Selective Activity of NKT Cell Agonist Enabled by Sulfonamide Hydrogen-Bond Design. J Med Chem. 2025 Aug 14;68 (15) :15785-15797.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CD1d
Curated Selection
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