Antiparasitic agent-27

Antiparasitic agent-27 (Compound 2) is a potent antiparasitic agent targeting Leishmania infantum (IC50=3.1 μM) . Antiparasitic agent-27 induces G0/G1 cell cycle arrest and reactive oxygen species (ROS) generation to trigger programmed cell death. Antiparasitic agent-27 is promising for research of visceral leishmaniasis (VL) [1].

Product Specifications

CAS Number

[3048504-54-4]

UNSPSC

12352005

Target

Parasite; Reactive Oxygen Species (ROS)

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Infection

Smiles

O=C(C1=CC=C(O)C=C1)N2CCN(C3=NC=CN=C3)CC2

Molecular Formula

C15H16N4O2

Molecular Weight

284.31

References & Citations

[1]Jacques Dit Lapierre T J W, et al. Hit-to-Lead Studies of Pyrazinylpiperazines against Visceral Leishmaniasis: Pharmacokinetic Profile and In Vivo Efficacy of Potent Compounds against Leishmania infantum[J]. ACS Pharmacology & Translational Science, 2025.