RORγ agonist 2
RORγ agonist 2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03 μM for hRORγ. RORγ agonist 2 significantly inhibits tumors growth in syngeneic MC38 tumor mice model[1].
Product Specifications
UNSPSC
12352005
Target
ROR
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CCS(=O)(C1CCN(C(C)=O)C(C(NC2=CC(F)=C(C(C(F)(F)F)=C2)OC3=CC(C4CC4)=NC(C5CC5)=C3)=O)C1)=O
Molecular Formula
C28H31F4N3O5S
Molecular Weight
597.62
References & Citations
[1]Fukuda S, et al. A Concise and Modular Approach to Generate Novel RORγ Agonists. J Med Chem. 2025 Jul 18.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RORα; RORγ
Curated Selection
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