USP7 Ligand-Linker Conjugates 1
USP7 Ligand-Linker Conjugates 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for USP7 (HY-175359) and a PROTAC linker, which recruits E3 ligases. USP7 Ligand-Linker Conjugates 1 can be used for synthesis of PROTAC USP7 Degrader-1 (HY-175358) [1].
Product Specifications
UNSPSC
12352005
Target
Deubiquitinase; Target Protein Ligand-Linker Conjugates
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.92
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(OC(C)(C)C)CCCCCOC1=CC=C(C2=C(C3=NN2C)N=CN(CC4(O)CCN(C(C[C@@H](C)C5=CC=CC=C5)=O)CC4)C3=O)C=C1
Molecular Formula
C38H49N5O6
Molecular Weight
671.83
References & Citations
[1]Wittenburg S, et al. Enhancing Solubility in VHL-Based PROTACs: Optimized USP7 Degraders for Improved Developability. J Med Chem. 2025 Jul 17.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
USP7
Available Sizes
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