PROTAC BET Degrader-13
PROTAC BET Degrader-13 (Compound 34) is a TRIM21-based PROTAC (TRIMTAC) degrader targeting BET. PROTAC BET Degrader-13 significantly degrades PML-eGFP-BRD4 fusion protein with a near-complete loss of EGFP+ nuclear puncta with an EC50 of 1.4 μM[1]. Pink: BET ligand ; Blue: E3 ligase ligand (HY-W1125585) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; PROTACs
Related Pathways
Epigenetics; PROTAC
Field of Research
Cancer
Smiles
O=C(C[C@H]1N=C(C2=C(N3C(C)=NN=C13)SC=C2C)C4=CC=C(C=C4)Cl)NCCOCCOCCOCc5cc(N6C(C7=CC=CC=C7N=C6CN8CCNC[C@@H]8C)=O)c(OCC)cc5
Molecular Formula
C47H54ClN9O6S
Molecular Weight
908.51
References & Citations
[1]Scemama de Gialluly MA, et al. Elaboration of molecular glues that target TRIM21 into TRIMTACs that degrade protein aggregates. Nat Commun. 2025 Jul 16;16 (1) :6548.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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