TriOncoFAP-GlyPro-MMAE

TriOncoFAP-GlyPro-MMAE is a small molecule drug conjugate (SMDC) targeting fibroblast activation protein (FAP) with an IC50 of 13 pmol/L. TriOncoFAP-GlyPro-MMAE combines a FAP-targeting ligand (TriOnco), a cleavable glycine-proline linker, and a cytotoxic payload (MMAE) [1].

Product Specifications

UNSPSC

12352005

Target

FAP

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(CCC(NC1=CC=CC2=C1N=CC=C2C(NCC(N3[C@@H](CC(F)(C3)F)C#N)=O)=O)=O)NCCNC(CCOCC(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@](CCC7)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C8=CC=CC=C8)O)=O)=O)=O)=O)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)(COCCC(NCCNC(CCC(NC9=CC=CC%10=C9N=CC=C%10C(NCC(N%11CC(F)(C[C@H]%11C#N)F)=O)=O)=O)=O)=O)COCCC(NCCNC(CCC(NC%12=C(C%13=CC=C%12)N=CC=C%13C(NCC(N%14CC(F)(C[C@H]%14C#N)F)=O)=O)=O)=O)=O)=O

Molecular Formula

C167H218F6N36O43S

Molecular Weight

3563.79

References & Citations

[1]Bocci M, et al. Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics. Mol Cancer Ther. 2025 Jun 30.