Nurr1 agonist 14
Nurr1 agonist 14 (Compound 32) is a Nurr1 agonist with an EC50 of 0.09 μM for Nurr1. Nurr1 agonist 14 has significant neuroprotective activity with no influence of residual DHODH inhibition. Nurr1 agonist 14 upregulates neuroprotective genes including SOD2, SESN3, BIRC5, XIAP, FLRT2 and CRMP4 in dopaminergic neurons. Nurr1 agonist 14 can be used for neurodegenerative diseases such as Alzheimer′s disease (AD), Parkinson′s disease (PD) and multiple sclerosis (MS) research[1].
Product Specifications
UNSPSC
12352005
Target
Calcium Channel; IAP; Nuclear Hormone Receptor 4A/NR4A; SOD; Survivin
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=C(C2=NN=NN2)CCC1)NC3=CC=C(C4=CC=CC(OC)=C4)C=C3F
Molecular Formula
C20H18FN5O2
Molecular Weight
379.39
References & Citations
[1]Stiller T, et al. Carboxylic Acid Bioisosteres Boost Nurr1 Agonist Selectivity. J Med Chem. 2025 Jul 17:10.1021/acs.jmedchem.5c01140.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Nurr1/NR4A2; XIAP
Available Sizes
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