HIV-1-IN-83
HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM[1].
Product Specifications
UNSPSC
12352005
Target
HIV; Reverse Transcriptase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
CC1=CC(C2=NN=C(O2)C3=CN=CC=C3)=CC(C)=C1OC4=C5SC=CC5=NC(NC6CCN(CC6)CC7=CC=C(C=C7)S(=O)(N)=O)=N4
Molecular Formula
C33H32N8O4S2
Molecular Weight
668.79
References & Citations
[1]Zhang T, et al. Probing the Dominant Motifs within the Hydrophobic Channel Yields Oxadiazole-Containing Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. J Med Chem. 2025 Jul 17.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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