HIV-1-IN-83

HIV-1-IN-83 (Compound 18E) is a HIV-1 non-nucleoside reverse transcriptase inhibitor with an IC50 of 0.45 μM for wild-type HIV-1 non-nucleoside reverse transcriptase. HIV-1-IN-83 has potent antiviral activity against both HIV-1 wild-type and mutant strains and improves antidrug resistance for Y188L and RES056 mutant strains. HIV-1-IN-83 has no significant toxicity up to 11.088 μM[1].

Product Specifications

UNSPSC

12352005

Target

HIV; Reverse Transcriptase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

CC1=CC(C2=NN=C(O2)C3=CN=CC=C3)=CC(C)=C1OC4=C5SC=CC5=NC(NC6CCN(CC6)CC7=CC=C(C=C7)S(=O)(N)=O)=N4

Molecular Formula

C33H32N8O4S2

Molecular Weight

668.79

References & Citations

[1]Zhang T, et al. Probing the Dominant Motifs within the Hydrophobic Channel Yields Oxadiazole-Containing Diarylpyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. J Med Chem. 2025 Jul 17.