OncoFAP-GlyPro-MMAE

OncoFAP-GlyPro-MMAE is a FAP small molecule-drug conjugate (SMDC) with an IC50 of 0.49 nM. OncoFAP-GlyPro-MMAE consists of a FAP Ligand OncoFAP (HY-145938), a Tubulin inhibitor (MMAE) (HY-15162) and a linker. OncoFAP-GlyPro-MMAE can be used for cancers like renal cancer research[1].

Product Specifications

CAS Number

[2688118-55-8]

UNSPSC

12352005

Target

FAP; Microtubule/Tubulin

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation

Field of Research

Cancer

Purity

99.71

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NCC(N1[C@H](C#N)CC(F)(F)C1)=O)C2=CC=NC3=C(NC(CCC(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@H](C(O)=O)CSC4C(N(CCCCCC(NCC(N5[C@H](C(NC6=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N7[C@](CCC7)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C8=CC=CC=C8)O)=O)=O)=O)=O)=O)C=C6)=O)CCC5)=O)=O)C(C4)=O)=O)=O)=O)=O)=O)=O)C=CC=C32

Molecular Formula

C102H141F2N19O27S

Molecular Weight

2135.38

References & Citations

[1]Bocci M, et al. Development of multivalent FAP-targeted Small Molecule-Drug Conjugates with tailored MMAE release kinetics. Mol Cancer Ther. 2025 Jun 30.