XB2M54

XB2M54 is a selective XIAP antagonist. XB2M54 inhibits NOD2-mediated inflammatory signaling. XB2M54 is an E3 ligase ligand. XB2M54 can be used for synthesis of PROTAC ERα Degrader-1 (HY-112098) [1].

Product Specifications

CAS Number

[1467165-30-5]

UNSPSC

12352005

Target

IAP; Ligands for E3 Ligase; NOD-like Receptor (NLR)

Related Pathways

Apoptosis; Immunology/Inflammation; PROTAC

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology; Others

Smiles

CN[C@H](C(N[C@@H]1C(N(C2=C(N([C@H]1C)C(C)=O)C=C(C#N)C=C2)CC3=C(C=CC4=C3C=CC=C4)OC)=O)=O)C

Molecular Formula

C29H31N5O4

Molecular Weight

513.59

References & Citations

[1]Shemorry A, et al. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases. Cell Chem Biol. 2025 May 15;32 (5) :694-709.e35.