OICR-41103
OICR-41103 is an effective, selective, cell-active DCAF1 small molecule chemical probe that targets the DCAF1 WDR domain and replaces the viral Vpr protein. The binding Ki value of OICR-41103 and DCAF1 is less than 2 nM[1].
Product Specifications
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Infection
Smiles
NC(C[C@@H](C1=CC=C(C(Cl)=C1)F)NC(C2=CNC(/C=C/C(N3CCCCC3)=O)=C2C4=C(C=C(C=C4)Cl)F)=O)=O
Molecular Formula
C28H26Cl2F2N4O3
Molecular Weight
575.43
References & Citations
[1]Kimani SW, et al. OICR-41103 as a chemical probe for the DCAF1 WD40 domain. Commun Biol. 2025 Jul 19;8 (1) :1076.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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