Rac1-IN-5

Rac1-IN-5 is a specific, reversible inhibitor of RAC1 (KD = 30 nM) . Rac1-IN-5 competes with guanine nucleotides for specific binding to RAC proteins, effectively blocking RAC1 activity and RAC1-dependent cellular functions. Rac1-IN-5 exhibits anti-tumor metastasis effects in vivo and can improve survival. Rac1-IN-5 can be used to study invasive cancers such as triple-negative breast cancer and colon cancer[1].

Product Specifications

CAS Number

[694515-65-6]

UNSPSC

12352100

Target

Acyltransferase; Akt; Ras

Related Pathways

GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

99.84

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=CC=C(C=C1)SCCC(NC2=CC=C(C=C2)S(NC3=CC(OC)=CC=C3OC)(=O)=O)=O

Molecular Formula

C24H26N2O5S2

Molecular Weight

486.60

References & Citations

[1]Dilasser F, et al. A Rac-specific competitive inhibitor of guanine nucleotide binding reduces metastasis in triple-negative breast cancer. Cell Rep Med. 2025 Jul 15;6 (7) :102233.