DHC-286
DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].
Product Specifications
CAS Number
2920443-08-7
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
Molecular Formula
C23H20F3N3O5
Molecular Weight
475.42
References & Citations
[1]Chase DH, et al. Design and Application of Cereblon-Recruiting Prodegraders. J Am Chem Soc. 2025 Jul 16;147 (28) :24527-24537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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