C-Met ligand-Linker Conjugate 1
C-Met ligand-Linker Conjugate 1 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for c-Met (HY-W425461) and a PROTAC linker (HY-151862), which recruits E3 ligases. c-Met ligand-Linker Conjugate 1 can be used for synthesis of PROTAC c-Met degrader-5 (HY-175320) [1].
Product Specifications
UNSPSC
12352005
Target
C-Met/HGFR; Target Protein Ligand-Linker Conjugates
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C1C=CC(C2=CC(C#N)=CC=C2)=NN1CC3=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CCN6CCNCC6)=CC=C3
Molecular Formula
C34H38N8O2
Molecular Weight
590.72
References & Citations
[1]Jia C, et al. Novel Highly Potent c-Met Degraders against a Broad Range of Cancers. J Med Chem. 2025 Jul 24;68 (14) :15176-15197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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