Apoptosis inducer 43
Apoptosis inducer 43 is an apoptosis inducer. Apoptosis inducer 43 can induce apoptosis, SubG0-G1 cell cycle arrest, secondary necrosis, and upregulate caspase-3, p53, and Bax/Bcl-2 expression in HCT116 cells. Apoptosis inducer 43 can inhibit tumor growth in a solid Ehrlich carcinoma (SEC) mouse model. Apoptosis inducer 43 can be used to study cancers such as colon cancer, leukemia, and non-small cell lung cancer[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; MDM-2/p53
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(NC1=CC=CC(C(/C=C/C2=CC=C(C3=CC=CC=C3)C=C2)=O)=C1)C([NH3+])CC4=CC=CC=C4.FC(F)(F)C([O-])=O
Molecular Formula
C32H27F3N2O4
Molecular Weight
560.56
References & Citations
[1]El-Haggar R, et al.. Amino acid-modified chalcone derivatives with in vitro and in vivo efficacy against colon cancer. Eur J Med Chem. 2025 Nov 5;297:117963. https://pubmed.ncbi.nlm.nih.gov/40695035/
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3
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