BTF-DNBS
BTF-DNBS is a glutathione (GSH) -responsive small-molecule photosensitizer (PS) . BTF-DNBS disrupts mitochondrial function and triggers Golgi-mediated pyroptosis, serving as a reactive oxygen species (ROS) generator. BTF-DNBS is promising for research of cancers[1].
Product Specifications
UNSPSC
12352005
Target
Pyroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
O=C1C2=C(OC(C3=CC=C(C=C3)N(C4=CC=C(C=C4)C5=CC=C(C=C5)C#N)C6=CC=C(C=C6)C7=CC=C(C=C7)C#N)=C1OS(=O)(C8=C(C=C(C=C8)[N+]([O-])=O)[N+]([O-])=O)=O)C=CC=C2
Molecular Formula
C47H27N5O9S
Molecular Weight
837.81
References & Citations
[1]Li Y, et al. Lysosome Escape and Golgi Apparatus Accumulation Drive Robust Pyroptosis Based on Sulfhydryl-Inspired Aggregation-Induced Emission Photosensitizers. J Med Chem. 2025 Aug 14;68 (15) :16446-16458.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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