LIBX-A403

LIBX-A403 (Compound 21) is a highly selective acyl-CoA synthetase long-chain family member 4 (ACSL4) inhibitor (IC50=0.049 μM) . LIBX-A403 blocks ACSL4-mediated ferroptosis-promoting phospholipid remodeling. LIBX-A403 is promising for research of cancers (e.g., triple-negative breast cancer) and neurodegenerative diseases (e.g., Parkinson’s disease) [1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Field of Research

Cancer; Neurological Disease

Smiles

O=C(C1=C(C2=CC(/C=C/C(OC)=O)=CC=C2O1)NC(C)=O)C3=CC=CC=C3

Molecular Formula

C21H17NO5

Molecular Weight

363.36

References & Citations

[1]Charnelle E, et al. Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties[J]. Journal of Medicinal Chemistry, 2025.