LIBX-A403
LIBX-A403 (Compound 21) is a highly selective acyl-CoA synthetase long-chain family member 4 (ACSL4) inhibitor (IC50=0.049 μM) . LIBX-A403 blocks ACSL4-mediated ferroptosis-promoting phospholipid remodeling. LIBX-A403 is promising for research of cancers (e.g., triple-negative breast cancer) and neurodegenerative diseases (e.g., Parkinson’s disease) [1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis
Related Pathways
Apoptosis
Field of Research
Cancer; Neurological Disease
Smiles
O=C(C1=C(C2=CC(/C=C/C(OC)=O)=CC=C2O1)NC(C)=O)C3=CC=CC=C3
Molecular Formula
C21H17NO5
Molecular Weight
363.36
References & Citations
[1]Charnelle E, et al. Discovery of Potent Acyl-CoA Synthetase Long-Chain Family Member 4 (ACSL4) Inhibitors with Antiferroptotic Properties[J]. Journal of Medicinal Chemistry, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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