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LIBX-A402

LIBX-A402 (Compound 15b) is a selective ACSL4inhibitor with an IC50 of 0.33 μM. LIBX-A402 significantly protects MDA-MB-231 and LUHMES cells from ferroptosis. LIBX-A402 can be used for cancer, ischemia-reperfusion injury and neurodegenerative diseases like Parkinson’s disease research[1].

Product Specifications

UNSPSC

12352005

Target

Ferroptosis

Related Pathways

Apoptosis

Field of Research

Cancer; Neurological Disease; Cardiovascular Disease

Smiles

O=C(C1=C(C2=CC(C)=CC=C2O1)NC(C)=O)C3=CC=CC=C3

Molecular Formula

C18H15NO3

Molecular Weight

293.32

References & Citations

[1]Mazhari Dorooee D, et al. LIBX-A401: A Novel Selective Inhibitor of Acyl-CoA Synthetase Long Chain Family Member 4 (ACSL4) and Its Binding Mode. Angew Chem Int Ed Engl. 2025 May;64 (19) :e202500518.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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