SARS-CoV-2-IN-116

SARS-CoV-2-IN-116 (Compound (S, S) -4) is a highly selective angiotensin-converting enzyme 2 (ACE2) inhibitor (pIC50=7.61) . SARS-CoV-2-IN-116 blocks the interaction between SARS-CoV-2 spike protein and ACE2. SARS-CoV-2-IN-116 is promising for research of COVID-19[1].

Product Specifications

UNSPSC

12352005

Target

Angiotensin-converting Enzyme (ACE) ; SARS-CoV

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

COC1=CC(OCCF)=CC(CN2C(C[C@@H](C(O)=O)N[C@@H](CC(C)C)C(O)=O)=CN=C2)=C1

Molecular Formula

C22H30FN3O6

Molecular Weight

451.49

References & Citations

[1]Wang X, et al. Synthesis and Inhibitory Assessment of ACE2 Inhibitors for SARS-CoV-2: An In Silico and In Vitro Study. J Org Chem. 2025 Aug 1;90 (30) :10941-10947.