SARS-CoV-2-IN-116
SARS-CoV-2-IN-116 (Compound (S, S) -4) is a highly selective angiotensin-converting enzyme 2 (ACE2) inhibitor (pIC50=7.61) . SARS-CoV-2-IN-116 blocks the interaction between SARS-CoV-2 spike protein and ACE2. SARS-CoV-2-IN-116 is promising for research of COVID-19[1].
Product Specifications
UNSPSC
12352005
Target
Angiotensin-converting Enzyme (ACE) ; SARS-CoV
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Infection
Smiles
COC1=CC(OCCF)=CC(CN2C(C[C@@H](C(O)=O)N[C@@H](CC(C)C)C(O)=O)=CN=C2)=C1
Molecular Formula
C22H30FN3O6
Molecular Weight
451.49
References & Citations
[1]Wang X, et al. Synthesis and Inhibitory Assessment of ACE2 Inhibitors for SARS-CoV-2: An In Silico and In Vitro Study. J Org Chem. 2025 Aug 1;90 (30) :10941-10947.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ACE
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