NOTA-IMB-RGD
NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1) . NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer) [1].
Product Specifications
UNSPSC
12352211
Target
Integrin; PD-1/PD-L1
Related Pathways
Cytoskeleton; Immunology/Inflammation
Field of Research
Cancer
Smiles
O=C(NCCCCC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C)C(N1CCC[C@H]1C(N[C@H](CC(N)=O)C(N[C@@H]([C@H](CC)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](CO)C(N[C@@H](C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CO)=O)CS)=O)=O)CC(C)C)=O)NC(CCCCNC(CN2CCN(CCN(CC2)CC(O)=O)CC(O)=O)=O)=O)COCCOCCNC(CCC(NCCCCC3NC([C@H](NC(CNC(C(NC([C@@H](NC3=O)CC4=CC=CC=C4)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)=O
Molecular Formula
C118H196N30O37S
Molecular Weight
2659.06
References & Citations
[1]Zhou Y, et al. Synthesis and Preclinical Evaluation of Dual-Targeted Molecular Tracer for Positron Emission Tomography Imaging of Programmed Cell Death Ligand‑1 and Integrin αvβ3. ACS Pharmacol Transl Sci. 2025 Jul 16;8 (8) :2465-2473.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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