NOTA-IMB-RGD

NOTA-IMB-RGD is a dual molecular probe targeting integrin αvβ3 and programmed death ligand-1 (PD-L1) . NOTA-IMB-RGD blocks the PD-1/PD-L1 signaling pathway and integrin αvβ3-overexpressing tumor vasculature. NOTA-IMB-RGD is promising for research of solid tumors co-expressing PD-L1 and αvβ3 (e.g., glioma, breast cancer) [1].

Product Specifications

UNSPSC

12352211

Target

Integrin; PD-1/PD-L1

Related Pathways

Cytoskeleton; Immunology/Inflammation

Field of Research

Cancer

Smiles

O=C(NCCCCC(C(N[C@H](C(N[C@@H]([C@@H](C)O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C)C(N1CCC[C@H]1C(N[C@H](CC(N)=O)C(N[C@@H]([C@H](CC)C)C(N[C@@H]([C@@H](C)CC)C(N[C@H](CO)C(N[C@@H](C)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)=O)=O)=O)=O)=O)CC(C)C)=O)CO)=O)CS)=O)=O)CC(C)C)=O)NC(CCCCNC(CN2CCN(CCN(CC2)CC(O)=O)CC(O)=O)=O)=O)COCCOCCNC(CCC(NCCCCC3NC([C@H](NC(CNC(C(NC([C@@H](NC3=O)CC4=CC=CC=C4)=O)CC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)=O

Molecular Formula

C118H196N30O37S

Molecular Weight

2659.06

References & Citations

[1]Zhou Y, et al. Synthesis and Preclinical Evaluation of Dual-Targeted Molecular Tracer for Positron Emission Tomography Imaging of Programmed Cell Death Ligand‑1 and Integrin αvβ3. ACS Pharmacol Transl Sci. 2025 Jul 16;8 (8) :2465-2473.