PROTAC c-Met degrader-6
PROTAC c-Met degrader-6 is a potent and orally active c-Met PROTACdegrader. PROTAC c-Met degrader-6 significantly induces the degradation of the c-Met protein with DC50s of 0.52 nM and 0.45 nM in EBC-1 and Hs746T. PROTAC c-Met degrader-6 almost abrogates the migratory and invasion abilities of tumor cells and significantly induces the apoptosis and blocks the cell cycle in the G0/G1 phase. PROTAC c-Met degrader-6 can be used for the study of various cancers such as non-small cell lung cancer and stomach cancer (Pink: c-Met ligand (HY-W425461) ; Blue: E3 ligand (HY-14658) ; Black: Linker (HY-20797) ) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; PROTACs
Related Pathways
Apoptosis; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C1NC(CCC1N(C(C2=CC(N3CCN(CC3)CCOC4=CN=C(N=C4)C5=CC=CC(CN6C(C=CC(C7=CC(C#N)=CC=C7)=N6)=O)=C5)=CC=C82)=O)C8=O)=O
Molecular Formula
C41H35N9O6
Molecular Weight
749.77
References & Citations
[1]Jia C, et al. Novel Highly Potent c-Met Degraders against a Broad Range of Cancers. J Med Chem. 2025 Jul 24;68 (14) :15176-15197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Met
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