PROTAC c-Met degrader-5
PROTAC c-Met degrader-5 (Compound D19) is an orally active c-Met PROTAC degrader with DC50s of 0.42 and 0.32 nM in EBC-1 and Hs746T cells, respectively. PROTAC c-Met degrader-5 significantly induces cell apoptosis, G1 cell cycle arrest, and inhibits cell migration and invasion. PROTAC c-Met degrader-5 has potent antiproliferative and degradation efficacy against c-Met-addicted cancer cells and Tepotinib (HY-14721) -resistant cancer cells[1]. Pink: c-Met ligand (HY-W425461) ; Blue: CRBN ligase ligand (HY-14658) ; Black: linker
Product Specifications
UNSPSC
12352005
Target
Apoptosis; c-Met/HGFR; PROTACs; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; PROTAC; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C1C=CC(C2=CC(C#N)=CC=C2)=NN1CC3=CC(C4=NC=C(C=N4)OCC5CCN(CC5)CCN6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9C(NC(CC9)=O)=O)=O)=CC=C3
Molecular Formula
C47H46N10O6
Molecular Weight
846.93
References & Citations
[1]Jia C, et al. Novel Highly Potent c-Met Degraders against a Broad Range of Cancers. J Med Chem. 2025 Jul 24;68 (14) :15176-15197.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal Adenosine A1R Antibody [CoraFluor 1]](https://cdn.genprice.uk/genprice/uk/genprice2.webp)
