Nogo-B-IN-1
Nogo-B-IN-1 ((S, R) -4v) is a covalent Nogo-B inhibitor. Nogo-B-IN-1 inhibits the progression of osteosarcoma (OS) by suppressing Nogo-B activity and the PI3K/AKT/NF-κB/Bcl-2 signaling pathway. Nogo-B-IN-1 inhibits the proliferation of OS 143B cells (IC50 = 0.28 µM) and induces apoptosis. Nogo-B-IN-1 can be used for OS targeting research[1].
Product Specifications
UNSPSC
12352005
Target
Akt; Apoptosis; Bcl-2 Family; NF-κB; PI3K
Related Pathways
Apoptosis; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(OC)[C@@](C1=CC=C(Cl)C=C1Cl)(OCC2=CC=CC=C2Cl)[C@@H](NC3=CC=C(NC(C=C)=O)C=C3)C(OCC)=O
Molecular Formula
C29H27Cl3N2O6
Molecular Weight
605.89
References & Citations
[1]Xue J, et al. Identification of Nogo-B as a potential therapeutic target of osteosarcoma via stereochemically selective covalent probes. Cell Death Dis. 2025 Jul 19;16 (1) :537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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