URAT1-IN-14
URAT1-IN-14 is a potent and orally active Urate transporter 1 (URAT1) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout[1].
Product Specifications
CAS Number
[2516232-89-4]
UNSPSC
12352005
Target
URAT1
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
O=C(C1(SC2=CC=CC=C2N3CCOC4=CC=CC=C34)CCC1)O
Molecular Formula
C19H19NO3S
Molecular Weight
341.42
References & Citations
[1]Wang Y, Zhang L, Shao M, Hou X, Yang Y, Yang Y, Ye F, Li X, Xiao Z. Discovery of novel benzomorpholine derivatives as potent URAT1 inhibitors with hypouricemic effects. Bioorg Med Chem Lett. 2025 Jul 14;128:130342.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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