GPR183 inverse agonist-1
GPR183 inverse agonist-1 (Compound 78) is a GPR183 inverse agonist. GPR183 inverse agonist-1 inhibits the GPR183-mediated Gi activation and β-arrestin2 recruitment, and blocks PBMC migration. GPR183 inverse agonist-1 can be used for inflammatory, autoimmune and neoplastic disorders research[1].
Product Specifications
CAS Number
2380033-51-0
UNSPSC
12352005
Target
Arrestin; EBI2/GPR183
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C(C1=CC=C(Br)C=C1)N(CC2)CCC2CN3C(C=CC(N4N=CC=C4)=N3)=O
Molecular Formula
C20H20BrN5O2
Molecular Weight
442.31
References & Citations
[1]Andersson L, et al. AI-Driven Virtual Screening and First-in-Class Conformational Biosensor Enable the Discovery of a GPR183 Inverse Agonist[J]. bioRxiv, 2025: 2025.06. 19.659764.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Arrestin-3/β-Arrestin 2
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