DMU759

DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research[1].

Product Specifications

CAS Number

3052352-22-1

UNSPSC

12352005

Target

Parasite

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

NC1=C2C(F)=C(F)C(SC3CCCCC3)=C(F)C2=NC(C)=N1

Molecular Formula

C15H16F3N3S

Molecular Weight

327.37

References & Citations

[1]Tulloch LB, et al. Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease. Sci Transl Med. 2025 Jul 9;17 (806) :eadu4564.