Xanthine oxidase-IN-17

Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O₂⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout[1].

Product Specifications

CAS Number

[185522-92-3]

UNSPSC

12352005

Target

Xanthine Oxidase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Smiles

COC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=C1

Molecular Formula

C17H16O4

Molecular Weight

284.31

References & Citations

[1]Yang C, et al. Molecular insights from multi-spectroscopy and computer simulations investigation on the xanthine oxidase inhibition by 2',4'-dimethoxy-4-hydroxychalcone. Bioorg Chem. 2025 Aug;163:108745.