Xanthine oxidase-IN-17
Xanthine oxidase-IN-17 is a potent xanthine oxidase (XOD) inhibitor with an IC50 of 298 nM and a Ki of 167 nM. Xanthine oxidase-IN-17 decreases the formation of O₂⁻ radical by inhibiting the catalytic activity of XOD to diminish the production of uric acid. Xanthine oxidase-IN-17 shows no cytotoxicity in AML-12 hepatocytes, while suppressing uric acid production. Xanthine oxidase-IN-17 can be used for the studies of hyperuricemia and subsequently to gout[1].
Product Specifications
CAS Number
185522-92-3
UNSPSC
12352005
Target
Xanthine Oxidase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Smiles
COC1=CC=C(C(/C=C/C2=CC=C(O)C=C2)=O)C(OC)=C1
Molecular Formula
C17H16O4
Molecular Weight
284.31
References & Citations
[1]Yang C, et al. Molecular insights from multi-spectroscopy and computer simulations investigation on the xanthine oxidase inhibition by 2',4'-dimethoxy-4-hydroxychalcone. Bioorg Chem. 2025 Aug;163:108745.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Frequently Asked Questions
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