TRK-IN-32

TRK-IN-32 is a potent TRK inhibitor. TRK-IN-32 potently inhibits TRKWT, TRKG595R and TRKG667C with IC50 values of 0.08 nM, 2.14 nM and 0.68 nM, respectively. TRK-IN-32 also demonstrates antiproliferative activity against a panel of Ba/F3 cell lines transformed with wild type, xDFG, solvent-front as well as gatekeeper mutant TRK fusion proteins. TRK-IN-32 induces apoptosis of Ba/F3-TRKAWT and Ba/F3-TRKAG667C cells.TRK-IN-32 can be used for the study of various cancers (such as thyroid cancer, secretory breast carcinoma) [1].

Product Specifications

CAS Number

[3044124-79-7]

UNSPSC

12352005

Target

Apoptosis; Trk Receptor

Related Pathways

Apoptosis; Neuronal Signaling; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Smiles

C[C@@H](C1=CC=C(C=N1)F)NC2=NN3C(C4=NNC(C5CC5)=C4)=CN=C3C=C2

Molecular Formula

C19H18FN7

Molecular Weight

363.39

References & Citations

[1]Xu Y, et al. Discovery of imidazo[1,2-b]pyridazine derivatives as potent TRK inhibitors for overcoming multiple resistant mutants. Bioorg Chem. 2025 Aug;163:108737.