AChE-IN-92
AChE-IN-92 (Compound L4R1-3) is a highly selective acetylcholinesterase (AChE) inhibitor (IC50=4.6 nM) . AChE-IN-92 blocks acetylcholine hydrolysis and elevates synaptic acetylcholine levels. AChE-IN-92 is promising for research of Alzheimer’s disease (AD) [1].
Product Specifications
CAS Number
2421120-68-3
UNSPSC
12352005
Target
Cholinesterase (ChE)
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Smiles
COC(C(OC)=C1)=CC2=C1N=CC=C2NC3=CC(CN(CC)CC)=C(O)C=C3
Molecular Formula
C22H27N3O3
Molecular Weight
381.47
References & Citations
[1]Sun D, et al. Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE/BChE inhibitors. Bioorg Chem. 2025 Aug;163:108747.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE
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