Hedgehog IN-11

Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM) [1].

Product Specifications

UNSPSC

12352005

Target

Apoptosis; DNA Methyltransferase; Hedgehog

Related Pathways

Apoptosis; Epigenetics; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

O=C(OC1=CC2=C(C3=C(C4=C2C=C(C(OC)=C4)OC)CN5CCC[C@]5(C3)[H])C=C1)C(N=N6)=CN6CC7=CC=C(C(F)(F)F)C=C7

Molecular Formula

C33H29F3N4O4

Molecular Weight

602.60

References & Citations

[1]Feng Z, et al. Discovery of 1,2,3-triazole derivatives of phenanthroindolizidine to reverse temozolomide resistance in glioblastoma. Bioorg Chem. 2025 Aug;163:108752.