Hedgehog IN-11
Hedgehog IN-11 is an orally active Hedgehog inhibitor. Hedgehog IN-11 downregulates the expression of O6-methylguanine-DNA methyltransferase (MGMT) to impair the Temozolomide (TMZ) (HY-17364) resistance by inhibiting the Hedgehog pathway. Hedgehog IN-11 shows improved inhibition of cell migration and invasion, and induced cell apoptosis in TMZ-resistant GBM cell lines. Hedgehog IN-11 is predicted by computer simulation to have good blood-brain barrier penetration. Hedgehog IN-11 can be used for the study of glioblastoma (GBM) [1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; DNA Methyltransferase; Hedgehog
Related Pathways
Apoptosis; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(OC1=CC2=C(C3=C(C4=C2C=C(C(OC)=C4)OC)CN5CCC[C@]5(C3)[H])C=C1)C(N=N6)=CN6CC7=CC=C(C(F)(F)F)C=C7
Molecular Formula
C33H29F3N4O4
Molecular Weight
602.60
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGMT
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