STAT-3/c-Src-IN-1
STAT-3/c-Src-IN-1 (Compound 12d) is a dual STAT-3 (IC50=0.844 μM) and c-Src (IC50=0.268 μM) inhibitor. STAT-3/c-Src-IN-1 blocks tumor cell proliferation, migration, and angiogenesis signaling pathways. STAT-3/c-Src-IN-1 exhibits potent anti-proliferative activity against melanoma (SK-MEL-2) and CNS cancer (SNB-75) cell lines (GI50=-5.75 μM and -5.63 μM), inducing tumor cell apoptosis via G0/G1 and G2/M phase cell cycle arrest. STAT-3/c-Src-IN-1 is promising for research of melanoma and glioblastoma[1].
Product Specifications
UNSPSC
12352005
Target
Apoptosis; Src; STAT
Related Pathways
Apoptosis; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=C(CN1C(C2=CC=CC=C2N=C1C)=O)N/N=C/C3=CN(C4=CC=C(C=C4)S(=O)(C)=O)N=C3C(C=C5)=CC=C5[N+]([O-])=O
Molecular Formula
C28H23N7O6S
Molecular Weight
585.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3
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